Product & ReviewsAntibodies

Anti-Mouse 4-1BB - Purified <i>In vivo </i>PLATINUM™ Functional Grade

Product Details

Cat. No.
C2835- 50 mg
Clonality
Monoclonal
Host
Rat
Leinco Technologies

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Description

4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-B, c-Jun and p38 downstream pathways. Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity. Furthermore, it can increase immune activity to eliminate tumors in mice. Agonistic anti-CD137 antibodies have been reported to stimulate a more intense immune system attack on cancers.

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Antigen: 4-1BB is expressed on activated B cells and T cells, macrophages, and dendritic cells.
  • Clone: 3H3
  • Conjugate: Low Endotoxin Functional Formulation, PLATINUM
  • Isotype: IgG2a
  • Gene: 21942

Handling

  • Quantity: 50 mg
  • Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

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