Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488
Product Details
- Cat. No.
- T627-100 µg
- Clonality
- Monoclonal
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Description
Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Clone: TR75-54.7
- Conjugate: DyLight® 488
- Isotype: IgG
- Gene: 21938
Handling
- Quantity: 100 µg
- Storage: This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- In Situ Hybridization (ISH)