Product & ReviewsAntibodies

Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488

Product Details

Cat. No.
T627- 50 µg
Clonality
Monoclonal
Leinco Technologies

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Description

Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.

Biological Information

  • Clonality: Monoclonal
  • Reactivity: Mouse
  • Clone: TR75-54.7
  • Conjugate: DyLight® 488
  • Isotype: IgG
  • Gene: 21938

Handling

  • Quantity: 50 µg
  • Storage: This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.

Applications

  • In Situ Hybridization (ISH)
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