Product & ReviewsAntibodies
Anti-Mouse CD25 - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- C1194- 25 mg
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2RA. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: CD25 is expressed in activated T cells and B cells, thymocyte subset, pre-B cells, T regulatory cells.
- Clone: PC61
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG1 λ
- Gene: 16184
Handling
- Quantity: 25 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.