Anti-Mouse CD25 - Purified <i>In vivo </i>PLATINUM™ Functional Grade

CD25, a 55 kD type I transmembrane glycoprotein, has been shown to play roles in lymphocyte differentiation, activation, and proliferation. Many resting memory T cells constitutively express IL2RA. It functions as the receptor for HTLV-1, resulting in its expression on neoplastic cells in adult T cell lymphoma/leukemia. CD25 (sIL-2R) has been used to track disease progression. Some additional clinical applications include Chagas disease, a disease characterized by a decline of CD25 expression on immune cells, and Multiple sclerosis, in which treatments with mAbs target CD25.

• Clonality: Monoclonal
• Host: Rat
• Reactivity: Mouse
• Antigen: CD25 is expressed in activated T cells and B cells, thymocyte subset, pre-B cells, T regulatory cells.
• Clone: PC61
• Conjugate: Low Endotoxin Functional Formulation, PLATINUM
• Isotype: IgG1 λ
• Gene: 16584

• Quantity: 1.0 mg, 100 mg, 25 mg, 5.0 mg, 50 mg
• Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

• Blocking (BA)
• Fluorescent Assay (FA)
• Immunoprecipitation (IP)
• Mass Cytometry (CyTOF)
• Western Blotting (WB)