Anti-Mouse CD275 - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- C2369- 50 mg
- Clonality
- Monoclonal
- Host
- Rat
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Description
B7-H2, also known as ICOSL and B7RP-1, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains. B7-H2 is expressed on B cells and macrophages. It binds to ICOS on activated T cells and thus delivers a positive costimulatory signal for optimal T cell function (1). ICOS and B7RP-I do not interact with proteins in the CD28-B7 pathway (2). The structural features of B7-H2 are crucial for its costimulatory function. B7-H2 constructs lacking either the IgC or IgV domain demonstrates that receptor binding is mediated solely by the IgV domain but requires the IgC domain for maintaining the structural integrity of the protein (3).
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: splenic B-cells, T-cells, dendritic cells and macrophages
- Clone: HK5.3
- Conjugate: GOLD
- Isotype: IgG2a
- Gene: 50723
Handling
- Quantity: 50 mg
- Storage: This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- In Situ Hybridization (ISH)