Product & ReviewsAntibodies
Anti-Mouse CD278 (ICOS) - Biotin
Product Details
- Cat. No.
- C2259
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
- Clone: 7E.17G9
- Conjugate: Biotin
- Isotype: IgG2b
- Gene: 54167
Handling
- Quantity: 50 µg
- Storage: This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.