Product & ReviewsAntibodies
Anti-Mouse CD278 (ICOS) - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- C2258
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
- Clone: 7E.17G9
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG2b κ
- Gene: 54167
Handling
- Quantity: 1.0 mg, 100 mg, 25 mg, 5.0 mg, 50 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- In Situ Hybridization (ISH)