Product & ReviewsAntibodies

Anti-Mouse CD278 (ICOS) - Purified <i>In vivo </i>GOLD™ Functional Grade

Product Details

Cat. No.
C2258-1.0 mg
Clonality
Monoclonal
Host
Rat
Leinco Technologies

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Description

CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Antigen: ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
  • Clone: 7E.17G9
  • Conjugate: GOLD, Low Endotoxin Functional Formulation
  • Isotype: IgG2b κ
  • Gene: 54167

Handling

  • Quantity: 1.0 mg
  • Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Applications

  • In Situ Hybridization (ISH)
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