Anti-Mouse CD278 (ICOS) - Purified <i>In vivo </i>PLATINUM™ Functional Grade

CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.

• Clonality: Monoclonal
• Host: Rat
• Reactivity: Mouse
• Antigen: ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
• Clone: 7E.17G9
• Conjugate: Low Endotoxin Functional Formulation, PLATINUM
• Isotype: IgG2b
• Gene: 100048841

• Quantity: 100 mg
• Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.