Product & ReviewsAntibodies
Anti-Mouse CD278 (ICOS) - Purified <i>In vivo </i>PLATINUM™ Functional Grade
Product Details
- Cat. No.
- C2851- 50 mg
- Clonality
- Monoclonal
- Host
- Rat
The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our Antibody Directory.
Description
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
- Clone: 7E.17G9
- Conjugate: Low Endotoxin Functional Formulation, PLATINUM
- Isotype: IgG2b
- Gene: 100048841
Handling
- Quantity: 50 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.