Anti-Mouse CD32/CD16 - Purified <i>In vivo </i>GOLD™ Functional Grade

CD16 is expressed in two forms: CD16a and CD16b. CD16a (γRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (γRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (γRIII) and CD16 (γRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.

• Clonality: Monoclonal
• Host: Rat
• Reactivity: Mouse
• Antigen: These receptors are present on B cells, monocyte/macrophages, NK cells, neutrophils, mast cells and dendritic cells.
• Clone: 2.4G2
• Conjugate: GOLD, Low Endotoxin Functional Formulation
• Isotype: IgG2b
• Gene: 14130 14131

• Quantity: 5.0 mg
• Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

• Immunohistochemistry (IHC)
• In Situ Hybridization (ISH)
• Western Blotting (WB)