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CD16 is expressed in two forms: CD16a and CD16b. CD16a (γRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (γRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (γRIII) and CD16 (γRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses.