Product & ReviewsAntibodies

Anti-Mouse CD54 (ICAM-1) (Clone YN1/1.7.4) - Purified

Product Details

Cat. No.
C2151-100 µg
Clonality
Monoclonal
Host
Rat
Leinco Technologies

The supplier does not provide quotations for this antibody through SelectScience. You can search for similar antibodies in our  Antibody Directory.

Description

ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Antigen: CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
  • Clone: YN1/1.7.4
  • Conjugate: Purified
  • Isotype: IgG2b κ
  • Gene: 15894

Handling

  • Quantity: 100 µg
  • Storage: This Purified Antibody is stable when stored at 2-8°C. Do not freeze.

Applications

  • In Situ Hybridization (ISH)
Specificity rating
Sensitivity rating
Quality rating
Write your own review

Product Overview

Links