Anti-Mouse CD54 (ICAM-1) (Clone YN1/1.7.4) - Purified
Product Details
- Cat. No.
- C2151-100 µg
- Clonality
- Monoclonal
- Host
- Rat
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Description
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
- Clone: YN1/1.7.4
- Conjugate: Purified
- Isotype: IgG2b κ
- Gene: 15894
Handling
- Quantity: 100 µg
- Storage: This Purified Antibody is stable when stored at 2-8°C. Do not freeze.
Applications
- In Situ Hybridization (ISH)