Product & ReviewsAntibodies
Anti-Mouse CD70 (Clone FR70) - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- C2402
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD70 is a 30-33 kD type II transmembrane glycoprotein and a member of the TNF superfamily. CD70 is the ligand for CD27; the binding of which delivers costimulatory signals to T cells and NK cells. CD70 is expressed on highly activated lymphocytes characteristic of T- and B-cell lymphomas. Because normal lymphocytes have low CD70 expression, it has been suggested that anti-CD70 antibodies may be a possible treatment for CD70 positive lymphomas. CD70-specific antibodies are currently under investigation for the treatment of hematological malignancies and renal cell carcinoma.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: CD70 is expressed by highly activated lymphocytes as found in T-cell and B-cell lymphomas.
- Clone: FR70
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG2b κ
- Gene: 21948
Handling
- Quantity: 0.5 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Blocking (BA)
- Fluorescent Assay (FA)
- Western Blotting (WB)