Product & ReviewsAntibodies
Anti-Mouse CD86 - APC
Product Details
- Cat. No.
- C2161
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes.
- Clone: GL1
- Conjugate: Allophycocyanin (APC)
- Isotype: IgG2a κ
- Gene: 12524
Handling
- Quantity: 100 µg, 200 µg, 50 µg
- Storage: This APC conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- Immunohistochemistry (IHC)
- In Situ Hybridization (ISH)