Product & ReviewsAntibodies
Anti-Mouse CTLA-4 (CD152) - Purified <i>In vivo </i>PLATINUM™ Functional Grade
Product Details
- Cat. No.
- C2444- 25 mg
- Clonality
- Monoclonal
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Description
CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Antigen: CTLA-4 is expressed on activated T and B lymphocytes.
- Clone: UC10-4F10-11
- Conjugate: Low Endotoxin Functional Formulation, PLATINUM
- Isotype: IgG1
- Gene: 12477
Handling
- Quantity: 25 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Depletion (Dep)
- Fluorescent Assay (FA)
- In Situ Hybridization (ISH)
- Western Blotting (WB)