Anti-Mouse CTLA-4 (Clone 9H10) - Purified <i>In vivo </i>PLATINUM™ Functional Grade
Product Details
- Cat. No.
- C2841- 25 mg
- Clonality
- Monoclonal
- Host
- Syrian 9
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Description
CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system.1 CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells.2,3 CTLA4 is potentially therapeutic in autoimmune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.
Biological Information
- Clonality: Monoclonal
- Host: Syrian 9
- Reactivity: Mouse
- Antigen: Activated T cells
- Clone: 9H10
- Conjugate: Low Endotoxin Functional Formulation, PLATINUM
- Isotype: IgG
- Gene: 12477
Handling
- Quantity: 25 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Activation (Act)
- Blocking (BA)
- Depletion (Dep)
- Fluorescent Assay (FA)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)
- In Situ Hybridization (ISH)
- Mass Cytometry (CyTOF)
- Western Blotting (WB)