Anti-Mouse Fas Ligand (Clone 101624)
Product Details
- Cat. No.
- F1074-25 µg
- Clonality
- Monoclonal
- Host
- Rat
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Description
Fas ligand (FasL) is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Fas ligand is a homotrimeric protein and signals through trimerization of FasR, which spans the membrane of the "target" cell. This trimerization usually leads to apoptosis, or cell death. Soluble Fas ligand is generated by cleaving membrane-bound FasL at a conserved cleavage site by the external serine matrix metalloproteinase MMP-7. Soluble FasL is less active than their membrane-bound counterparts and do not induce receptor trimerization and DISC formation. FasL is regarded as a potential target for immunotherapy.1
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Clone: 101624
- Conjugate: Purified No Carrier Protein
- Isotype: IgG1
Handling
- Quantity: 25 µg
- Storage: The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Applications
- ELISA (ELISA)
- Neutralization (Neut)