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Growth arrest-specific 6, also known as GAS6 is a growth factor1 that serves as a ligand for members of the Axl subfamily of receptor protein-tyrosine kinases.2 GAS6 is expressed in hematopoietic tissue.3 GAS6 function as a direct regulator of osteoclastic function; they give an insight into the role of these vitamin K-dependent ligands in bone resorption in vivo.2 GAS6 has a potential therapeutic target to minimize graft-versus-host disease (GVHD).4