Anti-Mouse IFNβ - Purified
Product Details
- Cat. No.
- I-440
- Clonality
- Monoclonal
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Description
Interferons (IFN) consist of two classes. The type I IFN class consists of 20 highly similar IFN-α proteins and a single IFN-ß protein. The second class, type II IFN, consists of a single protein, IFN-γ. IFN-α and IFN-ß signal through the same cell surface receptor IFNAR1 and have a similar range of biological activities including antiviral and antiproliferative activity. The type I IFNs also influence activation, growth and differentiation of T cells, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. IFN-ß has recently proven to be beneficial in patients with multiple sclerosis and could also be a potential therapy for rheumatoid arthritis. It is unclear what cellular mechanisms are involved in IFN-ß’s therapeutic effects, but they may be caused by a restoration of balance between pro- and anti-inflammatory cytokines.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Clone: MIB-5E9.1
- Conjugate: Purified
- Isotype: IgG
Handling
- Quantity: 50 µg, 500 µg
- Storage: This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at – 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications
- Blocking (BA)
- Immunoprecipitation (IP)
- Western Blotting (WB)