Anti-Mouse IFNβ - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- I-439- 100 mg
- Clonality
- Monoclonal
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Description
Interferons (IFN) consist of two classes. The type I IFN class consists of 20 highly similar IFN-α proteins and a single IFN-ß protein. The second class, type II IFN, consists of a single protein, IFN-γ. IFN-α and IFN-ß signal through the same cell surface receptor IFNAR1 and have a similar range of biological activities including antiviral and antiproliferative activity. The type I IFNs also influence activation, growth and differentiation of T cells, B cells, macrophages, NK cells and other cell types such as endothelial cells and fibroblasts. IFN-ß has recently proven to be beneficial in patients with multiple sclerosis and could also be a potential therapy for rheumatoid arthritis. It is unclear what cellular mechanisms are involved in IFN-ß’s therapeutic effects, but they may be caused by a restoration of balance between pro- and anti-inflammatory cytokines.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Antigen: Fibroblasts & epithelial cells
- Clone: MIB-5E9.1
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG
- Gene: 15977/a>
Handling
- Quantity: 100 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Western Blotting (WB)