Anti-Mouse IL-1 R1, Type 1 - PE
Product Details
- Cat. No.
- I-433
- Clonality
- Monoclonal
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Description
IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1α and IL-1ß exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1ß, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Antigen: T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells, neural cells
- Clone: JAMA-147
- Conjugate: R-phycoerythrin (PE)
- Isotype: IgG
Handling
- Quantity: 50 µg, 500 µg
- Storage: This R-PE conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- Immunoprecipitation (IP)
- Western Blotting (WB)