Product & ReviewsAntibodies

Anti-Mouse IL-12

Product Details

Cat. No.
I-330-100 µg
Clonality
Polyclonal
Host
Goat
Leinco Technologies

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Description

IL-12 plays a role in resistance against pathogens via the differentiation of naive T cells into Th1 cells. It stimulates the growth and function of T cells, blocks formation of new blood vessels, and contributes to antimycobacterial immune response. In addition, it promotes the production of IFN-γ and TNF-α and reduces IL-4 mediated suppression of IFN-γ. Consequently, this enhances the immunostimulatory and immunomodulatory effects of IFN-γ. In addition, there appears to be a link between IL-2 and the signal transduction of IL-12 in NK cells, which enhances the functional response of IL-12 via IFN-γ production and killing of target cells. Furthermore, IL-12 is thought to be associated with autoimmunity. IL-12 was shown to worsen the condition when administered to people already suffering from autoimmune diseases. Comparatively, inhibition of IL-12 (either through IL-12 gene knock-out in mice or treatment of mice with IL-12 mAbs) improved the disease.

Biological Information

  • Clonality: Polyclonal
  • Host: Goat
  • Reactivity: Mouse
  • Conjugate: Antigen Affinity Purified
  • Gene: 16159

Handling

  • Quantity: 100 µg
  • Storage: The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.

Applications

  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • In Situ Hybridization (ISH)
  • Mass Cytometry (CyTOF)
  • Neutralization (Neut)
  • Western Blotting (WB)
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