Anti-Mouse IL-1R (CD121a) - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- I-435
- Clonality
- Monoclonal
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Description
IL-1 binds two receptors, IL-1RI and IL-1RII. The ligands IL-1α and IL-1ß exert all of their various biological actions by binding IL-1RI. IL-1RII has a shortened cytoplasmic domain that is unable to transduce signals and therefore acts as a decoy receptor and competitively antagonizes the binding of IL-1α and IL-1ß, thereby reducing their biological effects. Binding of the ligands to IL-1RI is enhanced by an accessory protein, IL-1R-AcP. IL-1RI is expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. It is an 80 kD transmembrane glycoprotein.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Clone: JAMA-147
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG
- Gene: 16177/a>
Handling
- Quantity: 1.0 mg, 100 mg, 25 mg, 5.0 mg, 50 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Immunoprecipitation (IP)
- In Situ Hybridization (ISH)
- Western Blotting (WB)