Anti-Mouse IL-1β - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- I-437- 25 mg
- Clonality
- Monoclonal
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Description
Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes.1,2 IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease.3. The B122 antibody has been reported to neutralize the bioactivity of natural or recombinant IL-1β.
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Antigen: Monocytes, tissue macrophages, Langerhan cells, dendritic cells, T lymphocytes, B lymphocytes, natural killer (NK) cells and many other B cells, T cells, related monocytes
- Clone: B122
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG
- Gene: 16176/a>
Handling
- Quantity: 25 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Blocking (BA)
- Immunoprecipitation (IP)
- Western Blotting (WB)