Product & ReviewsAntibodies

Anti-Mouse IL-4 (Clone 11B11) - Purified <i>In vivo</i> GOLD™ Functional Grade

Product Details

Cat. No.
I-1071
Clonality
Monoclonal
Host
Rat
Leinco Technologies

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Description

IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1,2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3,4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6,7 and airway inflammation in patients with asthma8.

Biological Information

  • Clonality: Monoclonal
  • Host: Rat
  • Reactivity: Mouse
  • Antigen: IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils.
  • Clone: 11B11
  • Conjugate: GOLD, Low Endotoxin Functional Formulation
  • Isotype: IgG1 κ
  • Gene: 16189

Handling

  • Quantity: 1 mg, 100 mg, 25 mg, 5 mg, 50 mg
  • Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Applications

  • In Situ Hybridization (ISH)
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