Anti-Mouse IL-4 (Clone 11B11) - Purified <i>In vivo</i> GOLD™ Functional Grade
Product Details
- Cat. No.
- I-1071- 100 mg
- Clonality
- Monoclonal
- Host
- Rat
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Description
IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1,2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3,4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6,7 and airway inflammation in patients with asthma8.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils.
- Clone: 11B11
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG1 κ
- Gene: 16189
Handling
- Quantity: 100 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- In Situ Hybridization (ISH)