Anti-Mouse IL-4 (Clone BVD6-24G2) - Biotin
Product Details
- Cat. No.
- I-1109- 500 µg
- Clonality
- Monoclonal
- Host
- Rat
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Description
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Clone: BVD6-24G2
- Conjugate: Biotin
- Isotype: IgG1
- Gene: 16189
Handling
- Quantity: 500 µg
- Storage: This Biotin conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- Blocking (BA)
- Immunoprecipitation (IP)
- In Situ Hybridization (ISH)
- Mass Cytometry (CyTOF)