Anti-Mouse KLRG-1 - Purified
Product Details
- Cat. No.
- K154
- Clonality
- Monoclonal
- Host
- Syrian 9
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Description
Clone 2F1 monoclonal antibody reacts with the mouse Killer cell Lectin-like Receptor G1 (KLRG1), also know as MAFA. KLRG1 is a homodimer of glycosylated 30-38 kDa subunits and contains a cytoplasmic motif similar to the immunoreceptor tyrosine-based inhibitory motif (ITIM). Rat MAFA was identified as an antigen specific to rat mast cells; however, the expression of mouse KLRG1/MAFA using 2F1 has not been detected on the surface of mouse mast cell lines, bone marrow-derived mast cells, or peritoneal mast cells. This antigen is expressed on approximately one-third of mouse NK cells and a subset of T cells. MHC class I molecules regulate KLRG1 via interactions with class I-specific inhibitory Ly49 molecules and SHP-1 signaling. Although KLRG1 and Ly49 are both lectin-like inhibitory receptors that are regulated by class I MHC expression, the effects of this on cell surface expression of these molecules are opposing, and the underlying regulatory mechanisms distinct.
Biological Information
- Clonality: Monoclonal
- Host: Syrian 9
- Reactivity: Mouse
- Clone: 2F1
- Conjugate: Purified
- Isotype: IgG
- Gene: 50928
Handling
- Quantity: 100 µg, 50 µg, 500 µg
- Storage: This Purified Antibody is stable when stored at 2-8°C. Do not freeze.
Applications
- In Situ Hybridization (ISH)