Product & ReviewsAntibodies
Anti-Mouse NK1.1 - Purified <i>In vivo </i>PLATINUM™ Functional Grade
Product Details
- Cat. No.
- N268- 5.0 mg
- Clonality
- Monoclonal
- Host
- Mouse
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Description
NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. NK1.1 contains a transmembrane domain and a cytoplasmic domain that are characteristic of C-type lectins. The function of NK cells is to mediate cytotoxicity and to secrete cytokines after immune stimulation. NK1.1 has been correlated with lysis of tumor cells In vitro and rejection of bone marrow allografts In vivo. It is also involved in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 is commonly used as a mouse NK cell marker.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Mouse
- Antigen: NK-1.1 is encoded by the NKR-P1B/NKR-P1C gene and expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129.
- Clone: PK136
- Conjugate: Low Endotoxin Functional Formulation, PLATINUM
- Isotype: IgG2a κ
- Gene: 17059
Handling
- Quantity: 5.0 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Blocking (BA)
- Fluorescent Assay (FA)
- Western Blotting (WB)