Product & ReviewsAntibodies
Anti-Mouse Noggin
Product Details
- Cat. No.
- N207- 25 µg
- Clonality
- Polyclonal
- Host
- Goat
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Description
Noggin is a secreted glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis that inhibits TGF-β signal transduction by binding to TGF-β family ligands and preventing them from binding to their corresponding receptors. Noggin is expressed in condensing cartilage and immature chondrocytes.1 Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Noggin plays a crucial role in bone development, joint formation, and neural tube fusion.
Biological Information
- Clonality: Polyclonal
- Host: Goat
- Reactivity: Mouse
- Conjugate: Antigen Affinity Purified
- Gene: 18121
Handling
- Quantity: 25 µg
- Storage: The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Applications
- Fluorescent Assay (FA)
- In Situ Hybridization (ISH)