Product & ReviewsAntibodies
Anti-Mouse/Rat CD126 (IL-6Rα) - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- I-1185- 1.0 mg
- Clonality
- Monoclonal
- Host
- Rat
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Description
CD126 (IL-6Rα) is an 80 kD type I cytokine receptor α chain that is a member of the Ig superfamily that can form a heterodimer with IL-6Rβ chain to form the high affinity IL-6 receptor. The IL-6/IL-6R complex is a potent pleiotropic cytokine that mediates cell growth and differentiation and has significant involvement in immune response. Inadequate production of IL-6 and IL-6R are thought to play a part in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Antigen: CD126 is expressed on activated T and B cells, monocytes, hepatocytes and plasma cells.
- Clone: D7715A7 (15A7)
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG2b κ
- Gene: 16194
Handling
- Quantity: 1.0 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Applications
- Fluorescent Assay (FA)
- Western Blotting (WB)