Anti-Mouse Receptor Interacting Protein 3 (RIP3)
Product Details
- Cat. No.
- R1001- 1 mg
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3.1-3 RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.2,3
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Mouse
- Conjugate: Purified No Carrier Protein
Handling
- Quantity: 1 mg
- Storage: This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Applications
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blotting (WB)