Product & ReviewsAntibodies

Anti-Mouse TCR β chain - APC

Product Details

Cat. No.
T665-100 µg
Clonality
Monoclonal
Leinco Technologies

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Description

TCRβ antibody, clone H57-597, recognizes the beta chain of the T cell receptor (TCRβ), expressed on αβ thymocytes and T lymphocytes, as well as natural killer T (NKT) cells1. TCRβ is a transmembrane protein that consists of an amino-terminal variable region, a constant region, and a stalk segment covalently linked to the TCR alpha chain (TCRα) via a disulfide bond2. TCRα/β does not contain signaling domains and is instead noncovalently associated with the CD3 complex (TCR-CD3), essential for TCR signaling3,4. TCRα/β recognizes antigens bound to major histocompatibility complex (MHC) molecules, resulting in phosphorylation of CD3 ITAMs and subsequent T cell activation, proliferation, and survival5,6.

Biological Information

  • Clonality: Monoclonal
  • Reactivity: Mouse
  • Antigen: TCRβ is expressed on αβ thymocytes, peripheral T cells, and NKT cells.
  • Clone: H57-597
  • Conjugate: Allophycocyanin (APC)
  • Isotype: IgG
  • Gene: 21577

Handling

  • Quantity: 100 µg
  • Storage: This Allophycocyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze.

Applications

  • In Situ Hybridization (ISH)
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