Anti-Mouse TNFα - Purified <i>In vivo </i>GOLD™ Functional Grade
Product Details
- Cat. No.
- T258
- Clonality
- Monoclonal
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Description
The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity.1 It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites.2 TNF-α is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-α secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-α has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-α
Biological Information
- Clonality: Monoclonal
- Reactivity: Mouse
- Antigen: Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells
- Clone: TN3-19.12
- Conjugate: GOLD, Low Endotoxin Functional Formulation
- Isotype: IgG
- Gene: 21926/a>
Handling
- Quantity: 1.0 mg, 100 mg, 25 mg, 5.0 mg, 50 mg
- Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.