Product & ReviewsAntibodies

Anti-Mouse TNFα - Purified <i>In vivo </i>GOLD™ Functional Grade

Product Details

Cat. No.
T258
Clonality
Monoclonal
Leinco Technologies

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Description

The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity.1 It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites.2 TNF-α is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-α secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-α has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-α

Biological Information

  • Clonality: Monoclonal
  • Reactivity: Mouse
  • Antigen: Activated monocytes, neutrophils, macrophages, T cells, B cells, NK cells, LAK cells
  • Clone: TN3-19.12
  • Conjugate: GOLD, Low Endotoxin Functional Formulation
  • Isotype: IgG
  • Gene: 21926/a>

Handling

  • Quantity: 1.0 mg, 100 mg, 25 mg, 5.0 mg, 50 mg
  • Storage: Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

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