anti-p21/ WAF1 mouse monoclonal, WA-1, purified
Product Details
- Cat. No.
- 691725
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
WA-1 reacts with human and other mammalian p21, a tumor suppressor protein, belonging to the CDI family. The intracellular protein p21 is a 21 kDa protein, also known as wild-type p53-activated fragment 1 (WAF1). It is an inhibitor of cyclin-dependent kinases (Cdks) and of proliferating-cell nuclear antigen (PCNA). It is induced by wild type p53, but not by mutated p53, by mezerein (anti-leukemic compound) and by interferon-ß. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma and thyroid carcinoma).Positive control: MCF7 cells, UV treated fibroblasts, HeLa cells, skin, colon, or breast carcinoma.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Monkey, Mouse, Rat
- Antigen: human p21 protein
- Clone: WA-1
- Conjugate: unconjugated
- Isotype: IgG1 kappa
Handling
- Quantity: 1 mL (100 µg/ml)
- Storage: store at 2-8°C
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)
- Immunocytochemistry (ICC)
- Immunofluorescence (IF)
- Immunohistochemistry (IHC)