Anti-PCNA - PE
Product Details
- Cat. No.
- P106-100 µg
- Clonality
- Monoclonal
- Host
- Mouse
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Description
PCNA antibody, clone PC10, recognizes proliferating cell nuclear antigen (PCNA), also known as cyclin, a 36 kDa nuclear protein belonging to the DNA sliding clamp family. PCNA is a ring-shaped homotrimer that encircles and slides along DNA1,2. PCNA is an auxiliary protein of DNA polymerase δ and ε and tethers the polymerase catalytic unit to the DNA template for efficient DNA synthesis3-6. PCNA also contributes to chromatin remodeling, DNA repair, sister chromatid cohesion, and cell cycle control7. Expression levels of PCNA are associated with proliferation and transformation, and PCNA is commonly used as a marker for proliferating cells8,9. Antibodies to PCNA are detected in sera from patients with systemic lupus erythematosus (SLE)10. In addition, PCNA is a reliable diagnostic and prognostic biomarker for cancer, as tumor cells express high levels of PCNA11.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Rat
- Antigen: PCNA is a ubiquitous nuclear protein present in all cell cycle stages, with the highest expression in the early S phase. Anti-PCNA staining is almost entirely confined to the nucleus and may show a diffuse or granular pattern or a mixture of both.
- Clone: PC10
- Conjugate: R-phycoerythrin (PE)
- Isotype: IgG2a κ
- Gene: 5111
Handling
- Quantity: 100 µg
- Storage: This R-PE conjugate is stable when stored at 2-8°C. Do not freeze.
Applications
- Immunochromatography (IC)
- In Situ Hybridization (ISH)