Anti-SELL monoclonal antibody, clone FMC46 [FITC]
Product Details
- Cat. No.
- CABT-46541MH
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Mouse Anti-Human SELL monoclonal antibody for FC. Mouse anti Human CD62L antibody, clone FMC46 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of na?ve lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells or 100ul whole blood. Applications：FC
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Bovine, Cynomolgus Monkey, Dog (Canine), Human, Rhesus Monkey
- Conjugate: FITC
- Isotype: IgG2b
- Gene: 6402
Handling
- Quantity: 100 μg
- Storage: in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Flow Cytometry (FC)