Anti-TNFRSF18 monoclonal antibody, clone YGITR765 [R-PE]
Product Details
- Cat. No.
- CABT-47671RM
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rat
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Description
Rat Anti-Mouse TNFRSF18 monoclonal antibody for FC. This product recognises mouse CD357, also known as glucocorticoid-induced tumour necrosis factor receptor (mGITR) or Tnrfsf18, a member of the tumour necrosis superfamily. Mouse CD357 is predominantly expressed by CD4+/CD25+ T regulatory cells and on CD4+/CD25- cells upon activation. Studies demonstrate that mouse GITR ligand (mGITRL) can bind to CD357 and neutralise the suppressive effects of CD4+CD25+ regulatory T cells. CD357 signalling can also enhance the proliferation of na?ve and primed T cells, suggesting a key role for CD357 in the regulation of T cell-mediated immunity. Flow Cytometry Use 10ul of the suggested working dilution to label 106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. Applications：FC
Biological Information
- Clonality: Monoclonal
- Host: Rat
- Reactivity: Mouse
- Conjugate: R-PE
- Isotype: IgG2b
- Gene: 21936
Handling
- Quantity: 100 Tests
- Storage: Store at +4°C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- Enzyme Immunoassay (EIA)
- Flow Cytometry (FC)
- Immunohistochemistry (IHC)