Anti-TNFRSF9 monoclonal antibody, clone 17B5 [FITC]
Product Details
- Cat. No.
- CABT-47023HM
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Hamster
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Description
Hamster Anti-Mouse TNFRSF9 monoclonal antibody for FC. Hamster anti Mouse CD137 antibody, clone 17B5 recognizes mouse CD137, also known as 4-1BB ligand receptor, a member of the tumour necrosis factor superfamily. CD137 is a potent costimulatory receptor for the growth and functional maturation of activated T-cells in the presence of T-cell receptor signal. It is found on activated T-cells, NK cells, monocytes and dendritic cells. Signalling through CD137 triggers T-cell expansion, cytokine production and prevention of activation-induced death of effector T-cells. CD137-mediated activation is distinct from and independent of CD28. Antibody cross-linking of CD137 on NK cells stimulates the secretion of IFN-gamma, cellular proliferation, CD25 expression and responsiveness to IL-2 and is associated with tumour activity, but not cytotoxicity. Hamster anti Mouse CD137 antibody, clone 17B5 may be used to block CD137-mediated T-cell proliferation. Flow Cytometry Use 10ul of the suggested working dilution to label 1x106 cells in 100ul. The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity Fc receptors. Applications：FC
Biological Information
- Clonality: Monoclonal
- Host: Hamster
- Reactivity: Mouse
- Conjugate: FITC
- Isotype: IgG
- Gene: 21942
Handling
- Quantity: 100 μg
- Storage: in frost-free freezers is not recommended. This product should be stored undiluted. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Applications
- ELISA (ELISA)
- Flow Cytometry (FC)