Anti-TNFSF11 polyclonal antibody

Rabbit anti-Human TNFSF11 polyclonal antibody for ELISA, WB. Rabbit anti Human CD254 antibody recognizes the soluble form of human CD254, otherwise known as sRANKL, a 20kDa glycoprotein and member of the Tumour Necrosis Factor (TNF) superfamily, generated by proteolytic processing of the full-length CD254 membrane protein. CD254 is highly expressed by T lymphocytes and osteoblastic cells and plays a key role in the differentiation and activation of osteoclast precursors, acting as a ligand for both receptor activator of NF-KBeta (RANK) and the decoy receptor osteoprotegerin (OPG), which act as antagonists. Binding of CD254 to RANK is essential for the activation of osteoclastogenesis, stimulated by factors such as TNF-alpha, IL-1beta, IL-6 and IL-17, whereas binding to OPG neutralizes CD254, thereby inhibiting osteoclastogenesis. CD254 augments the dendritic cell (DC) stimulation of na?ve T cell proliferation and may be involved in the regulation of DC-T cell interactions. CD254 is also involved in apoptosis, through activation of the antiapoptotic kinase AKT/PKB and the mTOR/S6K signalling pathway. Applications：ELISA; WB

• Clonality: Polyclonal
• Host: Rabbit
• Reactivity: Human
• Conjugate: Biotin
• Isotype: Polyclonal IgG
• Gene: 8600

• Quantity: 50 μg
• Storage: in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

• ELISA (ELISA)
• Flow Cytometry (FC)