The adenomatous polyposis coli protein (APC) is a tumor suppressor that promotes rapid degradation of catenin-beta 1 (CTNNB1) and participates in Wnt signaling. The GSK3-beta protein kinase regulates its activity by phosphorylation. APC binds to PDZ domains of DLG1 and 3, to catenins, axin and MAPRE protein family including the EB members.
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat, Xenopus
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human APC.
- Clone: ABT-1033
- Isotype: Rabbit Ig
- Gene: P25054, NP_000029
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
- ELISA (ELISA)
- Western Blotting (WB)