ApoB Rabbit mAb
Product Details
- Cat. No.
- A4184
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Rabbit
Western blot - ApoB Rabbit mAb (A4184)
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Description
This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. [provided by RefSeq, Jul 2008]
Biological Information
- Clonality: Monoclonal
- Host: Rabbit
- Reactivity: Mouse, Rat
Handling
- Specificity: 5
Applications
1:1000 dilution detect good ApoB-100.
Western blot
In mice liver cell lysate, I got a single band of ApoB-100 with 1:1000 ab dilution. No ApoB-48 were detected in liver cell lysate which is expected.
Review Date: 17 Jun 2021 | ABclonal Technology
