Product & ReviewsAntibodies

APP Antibody

Product Details

Cat. No.
253113
Type
Primary Antibody
Clonality
Polyclonal
Host
Rabbit
Abbiotec

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Description

The Amyloid Protein Precursor (APP) is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, whereas others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). In addition, APP is associated with neurological disorders related to type II diabetes and Down's syndrome.

Biological Information

  • Clonality: Polyclonal
  • Host: Rabbit
  • Reactivity: Chicken, Dog (Canine), Human, Monkey, Mouse, Rat
  • Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the c-term region of rat amyloid prcursor protein.
  • Isotype: Rabbit Ig
  • Gene: P08592

Handling

  • Quantity: 0.1 ml
  • Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Applications

  • ELISA (ELISA)
  • Western Blotting (WB)
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