AQP2 (Ser261) Antibody
Product Details
- Cat. No.
- 252521
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Aquaporin-2 (AQP-2) forms a water specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. It is expressed in the renal collecting tubules. Defects in AQP-2 are a cause of autosomal recessive nephrogenic diabetes insipidus (ANDI), also known as diabetes insipidus nephrogenic type 2. It is characterized by excessive water drinking (polydypsia) and urine excretion (polyuria). AQP-2 belongs to the MIP/aquaporin (TC1.A.8) family. Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Bovine, Chicken, Dog (Canine), Human, Mouse
- Antigen: KLH-conjugated synthetic phosphopeptide encompassing a sequence surrounding Ser261 of human AQP2.
- Isotype: Rabbit Ig
- Modifications: Phosphospecific Antibody
- Gene: P34080
Handling
- Quantity: 0.1 ml
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Western Blotting (WB)