Product & ReviewsAntibodies
ASPP2 Antibody
Product Details
- Cat. No.
- 251646
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Description
Apoptosis-stimulating of p53 protein 2 (ASPP2) is a regulator that plays a central role in regulation of apoptosis and cell growth. ASPP2 regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. ASPP2 inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. ASPP2 impedes cell cycle progression at G2/M. The apoptosis-stimulating activity of ASPP2 is inhibited by its interaction with DDX42.
Biological Information
- Clonality: Polyclonal
- Host: Rabbit
- Reactivity: Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human ASPP2.
- Isotype: Rabbit Ig
- Gene: Q13625
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)