Product & ReviewsAntibodies
ATM phospho Ser1981 mouse antibody (mAb) (Clone 10H11.E.12), sample
Product Details
- Cat. No.
- 39530
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
ATM (Ataxia Telangiectasia Mutated) is a PI3-family protein kinase and a critical cell cycle checkpoint regulator. ATM and a related protein, ATR, play crucial roles in the maintenance of genome integrity and the response to DNA damage. Upon activation, ATM phosphorylates itself at serine 1981 and then phosphorylates a number of downstream proteins (e.g. BRCA1, CHK2, H2AX, P53, NBS1, SMC1) resulting in cell cycle arrest and the initiation of DNA damage repair. Loss of function of ATM is causal to a variety of syndromes involving increased incidence of several cancers.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human, Mouse
- Clone: 10H11.E.12
- Isotype: IgG1k
Handling
- Quantity: 10 ul
- Storage: Antibodies in solution can be stored at -20C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Applications
- Immunofluorescence (IF)