AURKB (13E) Antibody
Product Details
- Cat. No.
- 252689
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Description
Aurora B is involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Aurora B is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Aurora B phosphorylates 'Ser-10' and 'Ser-28' of histone H3 during mitosis, and is required for kinetochore localization of BUB1 and SGOL1.
Biological Information
- Clonality: Monoclonal
- Host: Mouse
- Reactivity: Human
- Antigen: Purified recombinant fragment of AURKB expressed in E. coli.
- Clone: 13E8D3
- Isotype: Mouse IgG1
- Gene: Q96GD4
Handling
- Quantity: 0.1 ml
- Storage: Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Applications
- Western Blotting (WB)