Product & ReviewsAntibodies
Bax Antibody
Product Details
- Cat. No.
- 250758
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Mouse
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Description
Apoptosis regulator BAX (BAX or Bcl-2-like protein 4) accelerates programmed cell death by binding to and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. BAX induces the release of cytochrome c, activation of caspase-3 and apoptosis. BAX forms heterodimers with BCL2, Bcl-X(L), MCL1 and A1 by interacting with BH3 domains in BIK, BID, BAK, and BAD. Defects in BAX are found in some cell lines from hematopoietic malignancies.
Biological Information
- Clonality: Polyclonal
- Host: Mouse
- Reactivity: Bovine, Dog (Canine), Human, Mouse, Rat
- Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human BAX.
- Isotype: Mouse Ig
- Gene: Q07812
Handling
- Quantity: 0.1 mg
- Storage: Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Applications
- ELISA (ELISA)
- Immunohistochemistry (IHC)
- Western Blotting (WB)